Sodium Hydroxide → HCID 20523282, compound

HRID 223219Notes

Reaction equation

HRID 223219 reaction equation
Cl[CH2:2][C:3]1[N:4]=[CH:5][N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[N:9]([CH3:18])[CH2:8][C:7]=12.[OH-].[Na+]>[Pd]>[CH3:2][C:3]1[N:4]=[CH:5][N:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[C:10](=[O:17])[N:9]([CH3:18])[CH2:8][C:7]=12

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20523292HCID 20523292, compound

Product 1

HCID 20523282HCID 20523282, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1.30 g (5 mmol) of 3-(chloromethyl)-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one and 200 mg (5 mmol) of sodium hydroxide are hydrogenated at room temperature and normal pressure in 20 ml of alcohol and in the presence of 100 mg of 10 percent palladium/carbon. The catalyst is removed, the solvent is evaporated and the residue is taken up in chloroform. The solution is washed with water, dried over magnesium sulphate and evaporated. There is obtained 4,5-dihydro-3,5-dimethyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 184.5°-185.5°.

Workup

  1. customare hydrogenated at room temperature
  2. customThe catalyst is removed
  3. customthe solvent is evaporated
  4. washThe solution is washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated

Sources & evidence

ORD record
ord-662b440fb487489999036b1bfd2082a9
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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