Sodium Hydroxide → HCID 20523282, compound

Participants

Reaction Steps

1.30 g (5 mmol) of 3-(chloromethyl)-4,5-dihydro-5-methyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one and 200 mg (5 mmol) of sodium hydroxide are hydrogenated at room temperature and normal pressure in 20 ml of alcohol and in the presence of 100 mg of 10 percent palladium/carbon. The catalyst is removed, the solvent is evaporated and the residue is taken up in chloroform. The solution is washed with water, dried over magnesium sulphate and evaporated. There is obtained 4,5-dihydro-3,5-dimethyl-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one of melting point 184.5°-185.5°.

Provenance & Evidence