Ethylene Oxide → HCID 86742540, compound

HRID 2232190Notes

Reaction equation

HRID 2232190 reaction equation
[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[C:5]([O:13][CH3:14])[CH:6]=[CH:7][C:8]=2[CH3:12])[NH:3]1.[CH2:15]1[O:17][CH2:16]1>C(O)C>[OH:17][CH2:16][CH2:15][N:3]1[C:4]2[CH:9]([CH:8]([CH3:12])[CH:7]=[CH:6][C:5]=2[O:13][CH3:14])[CH2:10][CH2:11][CH:2]1[CH3:1]

Participants

4

Reactant 2

HCID 6354Ethylene OxideHCID 14324234HCID 14324234, compound

Product 1

HCID 86742540HCID 86742540, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Next 355 parts of 2,5-dimethyl-8-methoxytetrahydroquinoline in 0.4 l ethanol with 86 parts ethylene oxide was reacted under pressure at 175° C. for 10 hours. The solvent was stripped under reduced pressure to an oil which eventually solidifed to give 97% N-(β-hydroxyethyl)-2,5-dimethyl-8-methoxytetrahydroquinoline.

Sources & evidence

ORD record
ord-467d069ab3494aa29c30634c1a77ac7a
Source dataset
uspto-grants-1988_11
Patent number
US04788121

Reaction notes

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