Sodium Hydroxide → HCID 54231756, compound

HRID 223220Notes

Reaction equation

HRID 223220 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]2[C:15]3[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=3[C:13](=[O:21])[N:12]3[CH2:22][CH2:23][CH2:24][C@H:11]3[C:10]=12)=[O:5])C.[OH-].[Na+]>O>[Cl:20][C:18]1[CH:17]=[CH:16][C:15]2[N:9]3[CH:8]=[N:7][C:6]([C:4]([OH:5])=[O:3])=[C:10]3[C@@H:11]3[CH2:24][CH2:23][CH2:22][N:12]3[C:13](=[O:21])[C:14]=2[CH:19]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10382951HCID 10382951, compound

Product 1

HCID 54231756HCID 54231756, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

7 g (20.2 mmol) of (S)-(+)-ethyl-7-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate and 950 mg (23.8 mmol) of sodium hydroxide are heated to boiling under reflux for 30 minutes in 20 ml of alcohol and 4 ml of water. After evaporation of the ethanol, the residue is made acid with 23.7 ml of 1 N hydrochloric acid. The white material obtained is filtered off under suction, washed with a small amount of water and dried. There is obtained (S)-7-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid of melting point 227°.

Workup

  1. customAfter evaporation of the ethanol
  2. customThe white material obtained
  3. filtrationis filtered off under suction
  4. washwashed with a small amount of water
  5. customdried

Sources & evidence

ORD record
ord-22522d7922554906ba277289ad2d123b
Source dataset
uspto-grants-1982_10
Patent number
US04352818

Reaction notes

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