Sodium Hydroxide → HCID 54231756, compound

Participants

Reaction Steps

7 g (20.2 mmol) of (S)-(+)-ethyl-7-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate and 950 mg (23.8 mmol) of sodium hydroxide are heated to boiling under reflux for 30 minutes in 20 ml of alcohol and 4 ml of water. After evaporation of the ethanol, the residue is made acid with 23.7 ml of 1 N hydrochloric acid. The white material obtained is filtered off under suction, washed with a small amount of water and dried. There is obtained (S)-7-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid of melting point 227°.

Provenance & Evidence