Triethylamine → HCID 14064612, compound

HRID 2232221Notes

Reaction equation

HRID 2232221 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=O.[NH:11]([C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]([Cl:23])=[N:15][N:14]=1)[NH2:12].C(N(CC)CC)C>O1CCOCC1>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]1[N:14]2[N:15]=[C:16]([Cl:23])[C:17]3[C:22]([C:13]2=[N:11][N:12]=1)=[CH:21][CH:20]=[CH:19][CH:18]=3

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 235422-Bromobenzoyl chlorideHCID 27937521-Chloro-4-hydrazinophthalazine

Product 1

HCID 14064612HCID 14064612, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 2-bromobenzoyl chloride (0.12 mole) in dioxane (50 ml) is added to a mixture of 1-hydrazino-4-chlorophthalazine (0.1 mole), triethylamine (0.12 mole) and dioxane (200 ml). The reaction mixture is refluxed for five hours then the solvent is evaporated off and the obtained residue is washed with a small amount of water and crystallized from methanol giving the compound of the title in 60% yield. M.p. 203°-04° C.

Workup

  1. temperatureThe reaction mixture is refluxed for five hours
  2. customthe solvent is evaporated off
  3. washthe obtained residue is washed with a small amount of water
  4. customcrystallized from methanol giving the compound of the title in 60% yield

Sources & evidence

ORD record
ord-e1bd9b3a679e4bcaacf577299d8e1c07
Source dataset
uspto-grants-1988_11
Patent number
US04788186

Reaction notes

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