1-(Methylamino)propan-2-ol → 2-Propanol, 1-((8-chloro-6-phenyl-1,2,4-triazolo(3,4-a)phthalazin-3-yl)methylamino)-

HRID 2232231Notes

Reaction equation

HRID 2232231 reaction equation
Cl[C:2]1[N:6]2[N:7]=[C:8]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:9]3[C:14]([C:5]2=[N:4][N:3]=1)=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=3.[OH:22][CH:23]([CH3:27])[CH2:24][NH:25][CH3:26]>C(O)C.C(Cl)(Cl)Cl>[Cl:15][C:11]1[CH:10]=[C:9]2[C:14](=[CH:13][CH:12]=1)[C:5]1=[N:4][N:3]=[C:2]([N:25]([CH2:24][CH:23]([OH:22])[CH3:27])[CH3:26])[N:6]1[N:7]=[C:8]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 860491-(Methylamino)propan-2-olHCID 212833453,8-Dichloro-6-phenyl-1,2,4-triazolo[3,4-a]phthalazine

Product 1

HCID 30712432-Propanol, 1-((8-chloro-6-phenyl-1,2,4-triazolo(3,4-a)phthalazin-3-yl)methylamino)-Yield 73%

Reagents, catalysts & solvents 1

HCID 21889567Chloroform ethanolSolvent

Procedure

The compound of the title is prepared by following substantially the same procedure outlined in example 122 but starting from 3,8-dichloro-6-phenyl-1,2,4-triazolo[3,4-a]phthalazine and (2-hydroxypropyl)methylamine. Yield: 73%. M.p. 236°-38° C. (from ethanol/chloroform).

Workup

  1. customThe compound of the title is prepared

Sources & evidence

ORD record
ord-0c34e8df8dbc4792a9e5937827f11030
Source dataset
uspto-grants-1988_11
Patent number
US04788186

Reaction notes

Loading…