HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2232232Generated: November 1, 2026
Sodium ethoxide → 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-3-ethoxy-6-phenyl-
https://huagongshe.com/reaction/2232232
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 3,8-Dichloro-6-phenyl-1,2,4-triazolo[3,4-a]phthalazine | HCID 21283345 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-3-ethoxy-6-phenyl- | HCID 3071244 | — |
Reaction Steps
A mixture of 3,8-dichloro-6-phenyl-1,2,4-triazolo[3,4-a]phthalazine (5 g), sodium ethoxide (1.3 g) and absolute ethanol (40 ml) is poured into a steel bomb and heated to 100° C. for 8 hours. Then the mixture is cooled and concentrated to dryness. The obtained residue is triturated with water, filtered and crystallized from ethanol/chloroform yielding 3.3 g of the compound of the title. M.p. 226°-28° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04788186 |
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| Source dataset | uspto-grants-1988_11 |
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| ORD ID | ord-17364f967c404d738d567aa56ee9dfc9 |
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| Source note | uspto-grants-1988_11 |
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