Piperidine → HCID 13799024, compound

HRID 2232245Notes

Reaction equation

HRID 2232245 reaction equation
S(O)(=O)(=O)C.[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14]O)[CH2:12][C:11]2=[CH:16][CH:17]=1.[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>C1(C)C=CC=CC=1>[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[CH2:12][C:11]2=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 131714665HCID 131714665, compound

Product 1

HCID 13799024HCID 13799024, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 5-methoxy-1-hydroxymethylbenzocyclobutene mesylate (38 g) and piperidine (45 ml) in toluene (180 ml) is refluxed under nitrogen for about 12 hours. The reaction mixture is filtered and the filtrate is evaporated in vacuo leaving a liquid residue which is used without further purification in the next step.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. customleaving a liquid residue which
  4. customis used without further purification in the next step

Sources & evidence

ORD record
ord-1b9c77780538478ca2c33cd078d1b61f
Source dataset
uspto-grants-1988_11
Patent number
US04788187

Reaction notes

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