Thiopheneethanamine → HCID 70056318, compound

HRID 2232324Notes

Reaction equation

HRID 2232324 reaction equation
[CH2:1]([C:4]1[N:5]([CH2:31][CH2:32][C:33]2[S:34][CH:35]=[CH:36][CH:37]=2)C(CCC)=C(C(OC)=O)C(C2C=CC(C(F)(F)F)=CC=2)[C:9]=1[C:10]([O:12][CH3:13])=[O:11])[CH2:2][CH3:3].NCCC1SC=CC=1.C(CC(OC)=O)(=O)CCC>>[S:34]1[CH:35]=[CH:36][CH:37]=[C:33]1[CH2:32][CH2:31][NH:5][C:4]([CH2:1][CH2:2][CH3:3])=[CH:9][C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 3

HCID 116521ThiopheneethanamineHCID 121700Methyl 3-oxohexanoateHCID 21283666HCID 21283666, compound

Product 1

HCID 70056318HCID 70056318, compound

Procedure

In a manner similar to that described in the preceding examples, dimethyl 2,6-di-(n-propyl)-4-(4-trifluoromethylphenyl)-1-[2-(2-thienyl)ethyl]-1,4-dihydropyridine-3,5-dicarboxylate is prepared by the reaction of (a) 2-(2-aminoethyl)thiophene and methyl butyrylacetate to obtain methyl 3-[2-(2-thienyl)ethyl]amino-2-hexenoate and (b) reacting the ester so obtained with 4-trifluoromethylbenzaldehyde in the presence of 2-(2-aminoethyl)thiophene and titanium tetrachloride.

Sources & evidence

ORD record
ord-5e8fc31d1f91436597e094913abf8b5a
Source dataset
uspto-grants-1988_11
Patent number
US04788203

Reaction notes

Loading…