Thiopheneethanamine → HCID 70056318, compound

Participants

Reaction Steps

In a manner similar to that described in the preceding examples, dimethyl 2,6-di-(n-propyl)-4-(4-trifluoromethylphenyl)-1-[2-(2-thienyl)ethyl]-1,4-dihydropyridine-3,5-dicarboxylate is prepared by the reaction of (a) 2-(2-aminoethyl)thiophene and methyl butyrylacetate to obtain methyl 3-[2-(2-thienyl)ethyl]amino-2-hexenoate and (b) reacting the ester so obtained with 4-trifluoromethylbenzaldehyde in the presence of 2-(2-aminoethyl)thiophene and titanium tetrachloride.

Provenance & Evidence