Allyl bromide → HCID 13922858, compound

HRID 2232344Notes

Reaction equation

HRID 2232344 reaction equation
[CH2:1](Br)[CH:2]=[CH2:3].[OH:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:13]=[C:12]([S:14](=[O:17])(=[O:16])[NH2:15])[S:11][C:10]=2[CH:18]=1.C([O-])([O-])=O.[K+].[K+]>CS(C)=O.O>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:13]=[C:12]([S:14](=[O:16])(=[O:17])[NH2:15])[S:11][C:10]=2[CH:18]=1)[CH:2]=[CH2:3]

Participants

6

Reactant 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 146921L 650719

Product 1

HCID 13922858HCID 13922858, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent2×

Procedure

Allyl bromide (2.07 ml, 24.0 mmol) was added dropwise to a stirred solution of 6-hydroxy-2-sulfamoylbenzo[b]thiophene (5.0 g, 22.0 mmol) in dimethylsulfoxide (15.0 ml). A solution of K2CO3 (3.34 g, 24.0 mmol) in water (7.5 ml) was added dropwise to the reaction solution at 25° C. After 24 hours, the reaction mixture was diluted with water (50 ml). The solid that formed was collected and dried, 3.75 gm (13.9 mmol), m.p. 101°-102° C.

Workup

  1. customThe solid that formed
  2. customwas collected
  3. customdried

Sources & evidence

ORD record
ord-895f993eb2d3471f9b292eacffb59206
Source dataset
uspto-grants-1988_11
Patent number
US04788192

Reaction notes

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