Bis(2-chloroethyl) ether → 5-Morpholinobenzo[b]thiophene

HRID 2232348Notes

Reaction equation

HRID 2232348 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.Cl[CH2:12][CH2:13][O:14][CH2:15][CH2:16]Cl.[OH-].[Na+]>>[O:14]1[CH2:15][CH2:16][N:1]([C:2]2[CH:10]=[CH:9][C:5]3[S:6][CH:7]=[CH:8][C:4]=3[CH:3]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 8115Bis(2-chloroethyl) etherHCID 14798Sodium HydroxideHCID 288032Benzo(b)thiophen-5-amine

Product 1

HCID 139229065-Morpholinobenzo[b]thiopheneYield 69.3%

Procedure

5-Aminobenzo[b]thiophene (5.4 g, 0.0362 mole), bis-(2-chloroethyl)ether (5.2 g, 0.0364 mole) and 40% aqueous NaOH (0.073 mole) were stirred vigorously and heated to refluxing for 22 hours. The cooled mixture was extracted with CHCl3. Evaporation of the washed and dried CHCl3 extract under reduced pressure left 7.0 g (88%) of the crude product as a slightly oily, dark yellow solid. This material was combined with 1.75 g of comparable crude product from a previous run. Recrystallization from CH3CN afforded 5.50 g of 5-morpholinobenzo[b]thiophene, m.p. 127°-132° C., that was characterized by nmr.

Workup

  1. temperatureheated
  2. temperatureto refluxing for 22 hours
  3. extractionThe cooled mixture was extracted with CHCl3
  4. customEvaporation of the
  5. washwashed
  6. extractiondried CHCl3 extract under reduced pressure
  7. waitleft 7.0 g (88%) of the crude product as a slightly oily, dark yellow solid
  8. customRecrystallization from CH3CN

Sources & evidence

ORD record
ord-6f0f2e7dd505499a8b7b300e1e114ccb
Source dataset
uspto-grants-1988_11
Patent number
US04788192

Reaction notes

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