Hydrochloric Acid → HCID 86741544, compound

HRID 2232358Notes

Reaction equation

HRID 2232358 reaction equation
C(OCC[C:7]1[CH:19]=[CH:18][C:10]2[S:11][C:12]([S:14](=[O:17])(=[O:16])[NH2:15])=[CH:13][C:9]=2[CH:8]=1)(=O)C.[OH-].[Na+].Cl.[CH2:23]([OH:25])[CH3:24]>>[OH:25][CH2:23][CH2:24][C:13]1[C:9]2[CH:8]=[CH:7][CH:19]=[CH:18][C:10]=2[S:11][C:12]=1[S:14](=[O:16])(=[O:17])[NH2:15]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 13922878HCID 13922878, compound

Product 1

HCID 86741544HCID 86741544, compoundYield 97%

Procedure

A solution of 5-(2-acetoxyethyl)-2-sulfamoyl benzo[b]thiophene, (1.8 g, 0.006 mol), ethanol (50 ml) and 10% NaOH (50 ml) was heated at reflux. After 4.5 h, the mixture was poured into 3N HCl (50 ml) and extracted with ethyl acetate (3×). The organic extracts were washed with saturated Na2CO3, dried, filtered and concentrated to dryness to yield 1.5 g (97%) of product, m.p. 162°-164° C.

Workup

  1. temperatureat reflux
  2. extractionextracted with ethyl acetate (3×)
  3. washThe organic extracts were washed with saturated Na2CO3
  4. customdried
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-38f5f9cb53b34b9abb283841005740bc
Source dataset
uspto-grants-1988_11
Patent number
US04788192

Reaction notes

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