Hydrochloric Acid → HCID 21283456, compound

HRID 2232367Notes

Reaction equation

HRID 2232367 reaction equation
[OH:1][C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]2[CH:9]=[C:8](C(O)=O)[S:7][C:6]=2[CH:13]=1.Cl>[Cu].N1C2C(=CC=CC=2)C=CC=1>[OH:1][C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]2[CH:9]=[CH:8][S:7][C:6]=2[CH:13]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 212834786-Hydroxy-5-methoxybenzo[b]thiophene-2-carboxylic acid

Product 1

HCID 21283456HCID 21283456, compound

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 7047QuinolineSolvent

Procedure

A mixture of the product from Step C (8 g), copper dust (2 g) and quinoline (40 mL) was heated under reflux for two hours. The hot reaction mixture was poured onto crushed ice (200 g), acidified with 6N hydrochloric acid and filtered. The filtrate was washed with saturated sodium chloride solution, dried (Na2SO4) and filtered and the solvent was evaporated in vacuo, leaving 5 g of waxy solid.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for two hours
  3. additionThe hot reaction mixture was poured
  4. filtrationfiltered
  5. washThe filtrate was washed with saturated sodium chloride solution
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. customthe solvent was evaporated in vacuo
  9. customleaving 5 g of waxy solid

Sources & evidence

ORD record
ord-3b25abe5e3b94148af2ff9ee9ae1597d
Source dataset
uspto-grants-1988_11
Patent number
US04788192

Reaction notes

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