HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(Trifluoromethyl)phenyl)thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetaldehyde, bromo- | HCID 105131 | — |
| Reactant | 4-(Trifluoromethyl)thiobenzamide | HCID 2734823 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-(Trifluoromethyl)phenyl)thiazole | HCID 14601969 | 49.3% |
Reaction Steps
In a manner similar to Step B of Example 1, the reaction of 10.0 grams (0.0487 mole) of (4-trifluoromethylphenyl)thiocarboxamide, 125 ml of ethanol, 8.35 grams (0.0490 mole) of bromoacetaldehyde, and 2 ml of concentrated hydrochloric acid produced 5.5 grams of 2-(4-trifluoromethylphenyl)thiazole as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788207 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-ac4e178a852d48deb970e67fa25c48a1 |
| Source note | uspto-grants-1988_11 |