Hydrochloric Acid → 2-(4-(Trifluoromethyl)phenyl)thiazole

HRID 2232390Notes

Reaction equation

HRID 2232390 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:11])=[S:10])=[CH:5][CH:4]=1.Br[CH2:15][CH:16]=O.Cl>C(O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:15]=[CH:16][N:11]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 105131Acetaldehyde, bromo-HCID 27348234-(Trifluoromethyl)thiobenzamide

Product 1

HCID 146019692-(4-(Trifluoromethyl)phenyl)thiazoleYield 49.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to Step B of Example 1, the reaction of 10.0 grams (0.0487 mole) of (4-trifluoromethylphenyl)thiocarboxamide, 125 ml of ethanol, 8.35 grams (0.0490 mole) of bromoacetaldehyde, and 2 ml of concentrated hydrochloric acid produced 5.5 grams of 2-(4-trifluoromethylphenyl)thiazole as a solid.

Sources & evidence

ORD record
ord-ac4e178a852d48deb970e67fa25c48a1
Source dataset
uspto-grants-1988_11
Patent number
US04788207

Reaction notes

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