HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiazole → 1-(5-Methylthien-2-yl)-2-(thiazol-2-yl)ethyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | (5-Methyl-2-thienylethynyl)trimethylsilane | HCID 14643579 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(5-Methylthien-2-yl)-2-(thiazol-2-yl)ethyne | HCID 21283715 | 41.8% |
Reaction Steps
In a manner similar to Step E of Example 3, the reaction of 7.96 gram (0.0410 mole) of 1-trimethylsilyl-2-(5-methylthien-2-yl)ethyne, 1.23 gram (3.9×10-4 mole) of tetrabutylammonium fluoride, and 2.6 gram (0.045 mole) of potassium fluoride in 120 ml of triethylamine and 40 ml of acetonitrile with 6.39 grams (0.0390 mole) of 2-bromothiazole yielded 3.35 grams of 1-(5-methylthien-2-yl)-2-(thiazol-2-yl)ethyne as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04788207 |
| Source dataset | uspto-grants-1988_11 |
| ORD ID | ord-02ddcd7fba824f1689f1ce3482ca3f01 |
| Source note | uspto-grants-1988_11 |