反应详情

In a manner similar to Step E of Example 3, the reaction of 7.96 gram (0.0410 mole) of 1-trimethylsilyl-2-(5-methylthien-2-yl)ethyne, 1.23 gram (3.9×10-4 mole) of tetrabutylammonium fluoride, and 2.6 gram (0.045 mole) of potassium fluoride in 120 ml of triethylamine and 40 ml of acetonitrile with 6.39 grams (0.0390 mole) of 2-bromothiazole yielded 3.35 grams of 1-(5-methylthien-2-yl)-2-(thiazol-2-yl)ethyne as an oil.