Methyl Isocyanate → HCID 54070895, compound

HRID 2232398Notes

Reaction equation

HRID 2232398 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[NH2:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[CH:8][CH:7]=1>CN(C)C=O>[CH3:1][NH:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[CH:10][CH:11]=1)=[O:4]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 108904611-(4-Aminophenyl)-4-(4-pyridyl)piperazine

Product 1

HCID 54070895HCID 54070895, compoundYield 52.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methyl isocyanate (0.18 g) was added to a stirred solution of 1-(4-aminophenyl)-4-(4-pyridyl)piperazine (0.51 g) in dry N,N-dimethylformamide (5 ml). The resulting mixture was stirred for 3 hours, diluted with a few ml. of ethanol and filtered. The solid was crystallised from methanol to give the title compound (0.33 g), m.p. 258°-260° C. Found: C,65.46; H,6.83; N,22.25. C17H21N5O requires: C,65.57; H,6.80; N,22.49%.

Workup

  1. additiondiluted with a few ml
  2. filtrationof ethanol and filtered
  3. customThe solid was crystallised from methanol

Sources & evidence

ORD record
ord-0286a15bb29d4de2a9b8486c59def8b8
Source dataset
uspto-grants-1988_11
Patent number
US04788196

Reaction notes

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