反应详情

A solution of 1-(4-aminophenyl)-4-(4-pyridyl)piperazine (0.50 g) and sulphamide (1.90 g) in dioxan (30 ml) was heated under reflux for 1 hour and then evaporated. The residue was triturated with water and the mixture was filtered. The solid was crystallised from a mixture of N,N-dimethylformamide and water to give the title compound (0.11 g), m.p. 216°-219° C. Found: C,54.03; H,5.59; N,20.68. C15H19N5O2S requires: C,54.05; H,5.75; N,21.01%.

1. temperatureunder reflux for 1 hour
2. customevaporated
3. customThe residue was triturated with water
4. filtrationthe mixture was filtered
5. customThe solid was crystallised from a mixture of N,N-dimethylformamide and water