1-(3-Chlorophenyl)piperazine → HCID 12686486, compound

HRID 223242Notes

Reaction equation

HRID 223242 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:17][CH3:18])=[CH:5][C:6]2[CH:12]([CH2:13][CH2:14]Cl)[O:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:16]=1.[Cl:19][C:20]1[CH:21]=[C:22]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:23]=[CH:24][CH:25]=1>C(O)CO.C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]([O:17][CH3:18])=[CH:5][C:6]2[CH:12]([CH2:13][CH2:14][N:29]3[CH2:28][CH2:27][N:26]([C:22]4[CH:23]=[CH:24][CH:25]=[C:20]([Cl:19])[CH:21]=4)[CH2:31][CH2:30]3)[O:11][CH2:10][CH2:9][CH2:8][C:7]=2[CH:16]=1

Participants

5

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 12686480HCID 12686480, compound

Product 1

HCID 12686486HCID 12686486, compoundYield 34.2%

Reagents, catalysts & solvents 2

HCID 174Ethylene GlycolSolventHCID 1140TolueneSolvent2×

Procedure

A mixture of 2.00 g (7.39 mmol) of 2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)]ethyl chloride and 2.8 g (14.5 mmol) of 1-(3-chlorophenyl)piperazine is stirred at 85° for 36 hours in 1 ml of ethylene glycol and 10 ml of toluene. Excess toluene is added and the solids are removed by filtration from the warm solution. The organic phase is concentrated. The product was recrystallized from CH2Cl2 and toluene to give 1.09 g of product, m.p. 125°-126°.

Workup

  1. customthe solids are removed by filtration from the warm solution
  2. concentrationThe organic phase is concentrated
  3. customThe product was recrystallized from CH2Cl2 and toluene

Sources & evidence

ORD record
ord-28deaae626674bdba73cfcdfa8b1331e
Source dataset
uspto-grants-1982_10
Patent number
US04352805

Reaction notes

Loading…