HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chlorophenyl)piperazine → HCID 12686486, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| Reactant | HCID 12686480 | HCID 12686480 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 12686486 | HCID 12686486 | 34.2% |
Reaction Steps
A mixture of 2.00 g (7.39 mmol) of 2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)]ethyl chloride and 2.8 g (14.5 mmol) of 1-(3-chlorophenyl)piperazine is stirred at 85° for 36 hours in 1 ml of ethylene glycol and 10 ml of toluene. Excess toluene is added and the solids are removed by filtration from the warm solution. The organic phase is concentrated. The product was recrystallized from CH2Cl2 and toluene to give 1.09 g of product, m.p. 125°-126°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04352805 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-28deaae626674bdba73cfcdfa8b1331e |
| Source note | uspto-grants-1982_10 |