Cyclohexylamine → HCID 10067435, compound

HRID 223247Notes

Reaction equation

HRID 223247 reaction equation
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:8](Cl)(=[O:26])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C1(C)C=CC=CC=1>[CH:1]1([NH:7][C:8](=[O:26])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 8212Stearoyl chloride

Product 1

HCID 10067435HCID 10067435, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
30 °C

Procedure

10 g of cyclohexylamine was dissolved in 80 ml of toluene. The resulting solution was cooled below 20° C. and 30 g of stearic acid chloride was added to the solution with stirring at temperatures below 20° C. The addition required one hour. The mixture solidified entirely. The solidified mixture was maintained at 30° C. for 2 hours. White crystals contained in the mixture was then filtered off, neutralized with alkaline alcohol and washed with water. The material so obtained was recrystallized from alcohol, from which it separated as white needles melting at 93.5° C. to 94.5° C. The yeild was 86%.

Workup

  1. temperatureThe resulting solution was cooled below 20° C.
  2. additionThe addition required one hour
  3. filtrationwas then filtered off
  4. washwashed with water
  5. customThe material so obtained
  6. customwas recrystallized from alcohol, from which it
  7. customseparated as white needles melting at 93.5° C. to 94.5° C

Sources & evidence

ORD record
ord-996e58ab13c84101bc31e39896d915fb
Source dataset
uspto-grants-1982_10
Patent number
US04352860

Reaction notes

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