Lithium hydroxide, monohydrate → HCID 54553774, compound

HRID 2232485Notes

Reaction equation

HRID 2232485 reaction equation
C([O:3][C:4](=[O:42])[CH2:5][CH2:6][C:7]1([CH3:41])[CH2:12][CH2:11][C:10]2[CH:13]=[C:14]([C:38](=[O:40])[CH3:39])[C:15]([O:20][CH2:21][CH2:22][CH2:23][O:24][C:25]3[CH:30]=[CH:29][C:28]([C:31](=[O:33])[CH3:32])=[C:27]([OH:34])[C:26]=3[CH2:35][CH2:36][CH3:37])=[C:16]([CH2:17][CH2:18][CH3:19])[C:9]=2[O:8]1)C.O.[OH-].[Li+]>O1CCCC1.O>[C:38]([C:14]1[C:15]([O:20][CH2:21][CH2:22][CH2:23][O:24][C:25]2[CH:30]=[CH:29][C:28]([C:31](=[O:33])[CH3:32])=[C:27]([OH:34])[C:26]=2[CH2:35][CH2:36][CH3:37])=[C:16]([CH2:17][CH2:18][CH3:19])[C:9]2[O:8][C:7]([CH3:41])([CH2:6][CH2:5][C:4]([OH:42])=[O:3])[CH2:12][CH2:11][C:10]=2[CH:13]=1)(=[O:40])[CH3:39]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 53996178HCID 53996178, compound

Product 1

HCID 54553774HCID 54553774, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

A 191 mg sample of the product from Example 26 was saponified with lithium hydroxide monohydrate, (273 mg) in 5 ml of 3:2 tetrahydrofuran-water, using the procedure described in Example 4. After column chromatography on silica gel, racemic-6-acetyl-7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)propoxy]-3,4-dihydro-2-methyl-8-n-propyl-2H-1-benzopyran-2-propanoic acid was obtained as a yellow, viscous oil.

Sources & evidence

ORD record
ord-92e46bd914a74f4c8f7f1a6eb2e4b097
Source dataset
uspto-grants-1988_11
Patent number
US04788214

Reaction notes

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