Dimethylformamide → Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

HRID 2232645Notes

Reaction equation

HRID 2232645 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

Product 1

HCID 10999320Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

Procedure

A solution of 2,3-dichloro-4,5-difluorobenzoic acid (9.3 g) and dimethylformamide (0.013 ml) in thionyl chloride (40 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation in nitrogen atmosphere to give the title compound (8.7 g) as pale yellow oil, bp 123°-126° C./40 mmHg.

Workup

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation in nitrogen atmosphere

Sources & evidence

ORD record
ord-ea06f8b905af4ef39127de398d3ba8e4
Source dataset
uspto-grants-1988_11
Patent number
US04788320

Reaction notes

Loading…