[1-[3-(3-Pyridinyl)propyl]-4-(3-pyridinyl)butyl]carbamic acid 1,1-dimethylethyl ester → alpha-[3-(3-Pyridinyl)propyl]-3-pyridinebutanamine

HRID 2232714Notes

Reaction equation

HRID 2232714 reaction equation
CC(OC(=O)[NH:7][CH:8]([CH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)[CH2:9][CH2:10][CH2:11][C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)(C)C>Cl>[N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([CH2:11][CH2:10][CH2:9][CH:8]([NH2:7])[CH2:18][CH2:19][CH2:20][C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[CH:13]=1

Participants

3

Reactant 1

HCID 15097556[1-[3-(3-Pyridinyl)propyl]-4-(3-pyridinyl)butyl]carbamic acid 1,1-dimethylethyl ester

Product 1

HCID 14994128alpha-[3-(3-Pyridinyl)propyl]-3-pyridinebutanamineYield 80%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

As in Example 37, hydrolysis of 5.4 g of [1-[3-(3-pyridinyl)-propyl)-4-(3-pyridinyl)butyl]carbamic acid 1,1-dimethylethyl ester in 55 mL of 1N HCl yielded 3.15 g of alpha-[3-(3-pyridinyl)propyl]-3-pyridinebutanamine.

Sources & evidence

ORD record
ord-d2fff979823544aa891a6154ec6eec84
Source dataset
uspto-grants-1988_11
Patent number
US04788206

Reaction notes

Loading…