反应详情

As in Example 134, a solution of (E)-5,5-bis(3- chlorophenyl)-2,4-pentadienoic acid 4-nitrophenyl ester (6.4 g) and 3-pyridinebutanamine (2.7 g) in tetrahydrofuran (75 mL) was stirred for 40 minutes at 40° C. and was worked up in the usual manner. The crude amide was purified by HPLC (ethyl acetate) and then crystallized from ethyl acetate-hexane to yield 5.1 g of (E)-5,5-bis(3-chlorophenyl)-N-[4-(3-pyridinyl)butyl]-2,4-pentadienamide, mp 100°-102° C.

1. customThe crude amide was purified by HPLC (ethyl acetate)
2. customcrystallized from ethyl acetate-hexane