Piperazine → 1-(3,4-Dichlorophenyl)piperazine

HRID 2232934Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([Cl:9])[CH:3]=1.[NH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[Cl:9][C:4]1[CH:3]=[C:2]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[Cl:8]

Participants

Reactant 2

HCID 4837Piperazine

HCID 290134-Bromo-1,2-dichlorobenzene

Product 1

HCID 936011-(3,4-Dichlorophenyl)piperazineYield 48.2%

Procedure

Beginning with 4-bromo-1,2-dichlorobenzene (200 mg, 0.88 mmol) and piperazine (91 mg, 1.06 mmol), 98 mg of the title compound was recovered by the procedure described in Example 1.

Sources & evidence

ORD record: ord-977ef84577d2439fbb7cbd128d3f00bf
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE041315E1

Reaction notes

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