3-Aminopropionitrile → 2-(1,3-benzothiazol-2-yl)ethanamine

HRID 2233009Notes

Reaction equation

HRID 2233009 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]#[N:5].N[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[SH:13]>CCO>[S:13]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:5]=[C:4]1[CH2:3][CH2:2][NH2:1]

Participants

4

Reactant 2

HCID 16473-AminopropionitrileHCID 87132-Aminothiophenol

Product 1

HCID 49625952-(1,3-benzothiazol-2-yl)ethanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 50 mg of 3-aminopropionitrile and 596 mg of 2-aminothiophenol in EtOH (15 mL) was heated at reflux for six h. After cooling the solution to room temperature, the reaction was concentrated and the residue was purified by silica gel chromatography to afford the title compound as a red oil. MS (M+H)+=179.1.

Workup

  1. temperatureat reflux for six h
  2. concentrationthe reaction was concentrated
  3. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-1fd12dcc2a8149c4a2a880aee1a32940
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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