HCID 68677268, compound → HCID 68675893, compound

HRID 2233031Notes

Reaction equation

HRID 2233031 reaction equation
[CH:1]([NH:4][C:5]1[C:6]2[N:7]([C:19](=[O:22])[NH:20][N:21]=2)[CH:8]=[C:9]([C:11]2(C(O)=O)[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:10]=1)([CH3:3])[CH3:2]>CC(O)=O.O>[CH:11]1([C:9]2[N:10]=[C:5]([NH:4][CH:1]([CH3:3])[CH3:2])[C:6]3[N:7]([C:19](=[O:22])[NH:20][N:21]=3)[CH:8]=2)[CH2:12][CH2:13][CH2:14][CH2:15]1

Participants

4

Reactant 1

HCID 68677268HCID 68677268, compound

Product 1

HCID 68675893HCID 68675893, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 20 mg of 1-(8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-6-yl)-cyclopentanecarboxylic acid in AcOH (3.0 mL) was warmed to 120° C. for 30 min. The reaction was cooled to ambient temperature and diluted with water. The mixture was extracted with EtOAc, the organic layer was washed with water (2×), dried over magnesium sulfate, filtered, and concentrated to leave the title compound as a tan solid. MS (M+H+)=262.3.

Workup

  1. extractionThe mixture was extracted with EtOAc
  2. washthe organic layer was washed with water (2×)
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-0f47e320f3314c088a9b4b59ba0b56bc
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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