Isopropylamine → HCID 68675824, compound

HRID 2233037Notes

Reaction equation

HRID 2233037 reaction equation
[Br:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:6]([C:8](=[O:11])[NH:9][N:10]=2)[CH:7]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>C1COCC1>[Br:1][C:2]1[N:3]=[C:4]([NH:16][CH:13]([CH3:15])[CH3:14])[C:5]2[N:6]([C:8](=[O:11])[NH:9][N:10]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 686778246-Bromo-8-chloro-1,2,4-triazolo[4,3-a]pyrazin-3(2H)-one

Product 1

HCID 68675824HCID 68675824, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.50 g of the product of Step D and 0.59 g of isopropylamine in THF (20 mL) was heated to reflux. After one h, the reaction was concentrated and the residue partitioned between EtOAc and water. The layers were separated and the organic phase was washed with sat sodium chloride solution, dried over magnesium sulfate, filtered, and concentrated to provide 6-bromo-8-isopropylamino-2H-[1,2,4]triazolo[4,3-a]pyrazin-3-one as a light tan solid. MS (M+H−)=271.2.

Workup

  1. concentrationAfter one h, the reaction was concentrated
  2. customthe residue partitioned between EtOAc and water
  3. customThe layers were separated
  4. washthe organic phase was washed with sat sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-df94e70fb5944557a1f307aa614df26c
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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