Hydrochloric Acid → HCID 68675803, compound

Participants

Reaction Steps

A solution of 720 mg of the product of Step F in dioxane (10 mL) was treated with 6N KOH (2.0 mL) and the mixture was stirred at ambient temperature. After six h, the pH of the reaction was adjusted to 4.0 with concentrated HCl and the mixture was extracted with 3:1 chloroform/IPA (3×). The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated to provide 8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid as a tan solid. MS (M+H+)=236.0.

Provenance & Evidence