Hydrochloric Acid → HCID 68675803, compound

HRID 2233039Notes

Reaction equation

HRID 2233039 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[C:7]([NH:15][CH:16]([CH3:18])[CH3:17])[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)=[O:4].[OH-].[K+].Cl>O1CCOCC1>[CH:16]([NH:15][C:7]1[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=1)([CH3:18])[CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 68676385HCID 68676385, compound

Product 1

HCID 68675803HCID 68675803, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 720 mg of the product of Step F in dioxane (10 mL) was treated with 6N KOH (2.0 mL) and the mixture was stirred at ambient temperature. After six h, the pH of the reaction was adjusted to 4.0 with concentrated HCl and the mixture was extracted with 3:1 chloroform/IPA (3×). The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated to provide 8-isopropylamino-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid as a tan solid. MS (M+H+)=236.0.

Workup

  1. extractionthe mixture was extracted with 3:1 chloroform/IPA (3×)
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-78eb3f95605d47589c04c659243c56b2
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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