Trifluoroacetic acid → HCID 68675419, compound

HRID 2233045Notes

Reaction equation

HRID 2233045 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11]1[C:12]2[N:13]([C:21](=[O:24])[NH:22][N:23]=2)[CH:14]=[C:15]([C:17]([CH3:20])([CH3:19])[CH3:18])[N:16]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH2:7][CH2:8][CH2:9][NH:10][C:11]1[C:12]2[N:13]([C:21](=[O:24])[NH:22][N:23]=2)[CH:14]=[C:15]([C:17]([CH3:18])([CH3:19])[CH3:20])[N:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68678344HCID 68678344, compound

Product 1

HCID 68675419HCID 68675419, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 100 mg of [2-(6-tert-butyl-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8-ylamino)-ethyl]-carbamic acid tert-butyl ester in dichloromethane (5.0 mL) was treated with 1.48 g of TFA at ambient temperature for 16 h. The solvent was removed and the residue was recrystallized from ether to afford the title compound as a white solid. MS (M+H+)=251.3.

Workup

  1. customThe solvent was removed
  2. customthe residue was recrystallized from ether

Sources & evidence

ORD record
ord-2bd098cb19354b2a8440b14e9f33eb60
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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