HCID 68676710, compound → HCID 68677961, compound

HRID 2233049Notes

Reaction equation

HRID 2233049 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([NH:19][CH:20]([CH3:22])[CH3:21])[C:7]2[N:8]([C:15](=[O:18])[NH:16][N:17]=2)[C:9]=1[CH:10]=[CH:11][CH:12]([CH3:14])[CH3:13])([CH3:3])[CH3:2]>CCO.[Pd]>[CH:1]([C:4]1[N:5]=[C:6]([NH:19][CH:20]([CH3:22])[CH3:21])[C:7]2[N:8]([C:15](=[O:18])[NH:16][N:17]=2)[C:9]=1[CH2:10][CH2:11][CH:12]([CH3:13])[CH3:14])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 68676710HCID 68676710, compound

Product 1

HCID 68677961HCID 68677961, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 30 mg of 6-isopropyl-8-isopropylamino-5-(3-methyl-but-1-enyl)-2H-[1,2,4]triazolo[4,3-a]pyrazin-3-one in EtOH (10 mL) was treated with 50 mg of 10% Pd/C. The mixture was hydrogenated at 35 psi for one h and the solids were removed by filtration through diatomaceous earth. The filtrate was concentrated to provide the title compound as a white solid. MS (M+H+)=304.4.

Workup

  1. customthe solids were removed by filtration through diatomaceous earth
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-2f95526bce4d470eb61c7076bdcd2d3b
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

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