2-(6-Methoxypyridin-3-yl)ethan-1-amine → HCID 11198658, compound

HRID 2233050Notes

Reaction equation

HRID 2233050 reaction equation
[C:1]([C:5]1[N:6]=[C:7](Cl)[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][O:17][C:18]1[N:23]=[CH:22][C:21]([CH2:24][CH2:25][NH2:26])=[CH:20][CH:19]=1>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([NH:26][CH2:25][CH2:24][C:21]2[CH:22]=[N:23][C:18]([O:17][CH3:16])=[CH:19][CH:20]=2)[C:8]2[N:9]([C:11](=[O:14])[NH:12][N:13]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 534075502-(6-Methoxypyridin-3-yl)ethan-1-amineHCID 68676527HCID 68676527, compound

Product 1

HCID 11198658HCID 11198658, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 50 mg of 6-tert-butyl-8-chloro-2H-[1,2,4]triazolo[4,3-a]pyrazin-3-one and 68 mg of 2-(6-methoxy-pyridin-3-yl)-ethylamine in THF (2 mL) was heated in a microwave apparatus (Emrys-Optimizer®, Personal Chemistry Inc., 2 Hampshire St., Suite 100, Foxboro, Mass.) at 150° C. for 10 min. The solvent was removed and the residue was purified by silica gel chromatography to afford the title compound as a white solid after trituration. MS (M+H+)=343.3.

Workup

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-13d4300ce3fb4e23bbdbf2d491a96543
Source dataset
uspto-grants-2010_05
Patent number
US07709473B2

Reaction notes

Loading…