HCID 12042841, compound → HCID 12042839, compound

HRID 2233062Notes

Reaction equation

HRID 2233062 reaction equation
[CH3:1][N:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N+:23]([O-])=O)[C:3]1[CH:12]=[CH:11][C:10]2[C:9]([CH3:14])([CH3:13])[CH2:8][CH2:7][C:6]([CH3:16])([CH3:15])[C:5]=2[CH:4]=1>CCO.[Pd]>[CH3:1][N:2]([C:3]1[CH:12]=[CH:11][C:10]2[C:9]([CH3:14])([CH3:13])[CH2:8][CH2:7][C:6]([CH3:16])([CH3:15])[C:5]=2[CH:4]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[NH2:23]

Participants

4

Reactant 1

HCID 12042841HCID 12042841, compound

Product 1

HCID 12042839HCID 12042839, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of methyl(2-nitrophenyl)(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphtalen-2-yl)amine (12) (R4=CH3, 0.26 mol) in EtOH (3200 mL) is treated with 10% Pd/C (8.9 g) under hydrogen atmosphere at room temperature for 2.5 h. After filtration of the catalyst, the filtrate is evaporated to give the above diamine (13) (R4=CH3).

Workup

  1. filtrationAfter filtration of the catalyst
  2. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-b4a59281122d496982f0ff8dfe8ba774
Source dataset
uspto-grants-2010_05
Patent number
US07709470B2

Reaction notes

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