反应详情

To a solution of ethyl N-trifluoroacetyl-N-(dichlorophosphonomethyl)glycinate (6.6 g, 0.02 mole) in 200 ml. of ether was added propylamine (4.7 g, 0.08 mole) in 50 ml. of ether. The reaction was stirred at room temperature for several hours, then the reaction mixture was filtered and the filtrate concentrated in vacuo. The residue was dissolved in 100 ml. ether, washed with water, dried over MgSO4, and concentrated in vacuo to yield ethyl N-trifluoroacetyl-N-(bis(propylamino)phosphonomethyl)glycinate (5.1 g), ND =1.4546.

1. filtrationthe reaction mixture was filtered
2. concentrationthe filtrate concentrated in vacuo
3. dissolutionThe residue was dissolved in 100 ml
4. washether, washed with water
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo