Methanol → HCID 57438738, compound

HRID 2233078Notes

Reaction equation

HRID 2233078 reaction equation
Br[C:2]1[N:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.[OH-:18].[Na+].[CH3:20]O>O>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:10]=[C:5]3[CH:4]=[N:3][C:2]([O:18][CH3:20])=[CH:7][N:6]3[CH:8]=2)=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57438739HCID 57438739, compound

Product 1

HCID 57438738HCID 57438738, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6-Bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyrazine (prepared from General Procedure B with 5-bromo-2-aminopyrazine and 2-bromo-4′-fluoroacetophenone, 1.05 g, 3.59 mmol), and 10% sodium hydroxide (6 mL) were combined in MeOH (12 mL). The reaction was heated in the microwave at 150 watts to about 100° C. for about 30 minutes. The reaction was cooled, diluted with water (50 mL), and filtered to provide 2-(4-fluorophenyl)-6-methoxyimidazo[1,2-a]pyrazine (0.513 g, 59%) on drying: LC/MS (Table 1, Method b) Rt=1.74 min; MS m/z: 244.2 (M+H)+.

Workup

  1. temperatureThe reaction was heated in the microwave at 150 watts to about 100° C. for about 30 minutes
  2. temperatureThe reaction was cooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-40b0d642c7b3450d9dcc2022b5bed863
Source dataset
uspto-grants-2010_05
Patent number
US07709468B2

Reaction notes

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