Methanol → HCID 57438738, compound

Participants

Reaction Steps

6-Bromo-2-(4-fluorophenyl)-imidazo[1,2-a]pyrazine (prepared from General Procedure B with 5-bromo-2-aminopyrazine and 2-bromo-4′-fluoroacetophenone, 1.05 g, 3.59 mmol), and 10% sodium hydroxide (6 mL) were combined in MeOH (12 mL). The reaction was heated in the microwave at 150 watts to about 100° C. for about 30 minutes. The reaction was cooled, diluted with water (50 mL), and filtered to provide 2-(4-fluorophenyl)-6-methoxyimidazo[1,2-a]pyrazine (0.513 g, 59%) on drying: LC/MS (Table 1, Method b) Rt=1.74 min; MS m/z: 244.2 (M+H)+.

Provenance & Evidence