反应详情

温度

50 °C

A mixture of MeOH (18 mL) and sodium (1.1 g, 48 mmol) was stirred at ambient temperature until the sodium was consumed then 8-chloro-2-(4-fluorophenyl)-imidazo[1,2-a]pyrazine (prepared from general procedure B using 3-chloropyrazin-2-ylamine and 2-bromo-1-(4-fluorophenyl)-ethanone; 1.0 g, 4 mmol) was added. The mixture was heated at about 50° C. for about 1 h. The mixture was cooled to ambient temperature and filtered. The beige solid isolated was carried on crude. (0.98 g, 100%): LC/MS (Table 1, Method b) Rt=1.8 min; MS m/z: 244.1 (M+H)+.

1. customwas consumed
2. temperatureThe mixture was cooled to ambient temperature
3. filtrationfiltered
4. customThe beige solid isolated