3,4-Dichloroaniline → 2-(3,4-Dichlorophenylamino)-4-thiocyanato-5-nitro-pyrimidine

HRID 2233138Notes

Reaction equation

HRID 2233138 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].Cl[C:11]1[N:16]=[C:15]([S:17][C:18]#[N:19])[C:14]([N+:20]([O-:22])=[O:21])=[CH:13][N:12]=1>C(O)C.C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:11]2[N:16]=[C:15]([S:17][C:18]#[N:19])[C:14]([N+:20]([O-:22])=[O:21])=[CH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

5

Reactant 2

HCID 72573,4-DichloroanilineHCID 210775882-Chloro-5-nitropyrimidin-4-yl thiocyanate

Product 1

HCID 210774632-(3,4-Dichlorophenylamino)-4-thiocyanato-5-nitro-pyrimidine

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

2.47 g of 3,4-dichloroaniline in 12 ml ethanol are added to 3.00 g of 2-chloro-4-thiocyanato-5-nitro-pyrimidine in 40 ml toluene at ambient temperature. The mixture is stirred for another 16 hours, the solid is suction filtered, washed twice with 30 ml toluene and then once with 30 ml of ethanol and dried.

Workup

  1. filtrationfiltered
  2. washwashed twice with 30 ml toluene
  3. dry with materialonce with 30 ml of ethanol and dried

Sources & evidence

ORD record
ord-7fc78009b75d4d75b608e0a2f198ad28
Source dataset
uspto-grants-2010_05
Patent number
US07709480B2

Reaction notes

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