Hydrochloric Acid → HCID 21081086, compound

HRID 2233149Notes

Reaction equation

HRID 2233149 reaction equation
C([NH:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH:9]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:8][CH2:7]1)(=O)C.Cl>CC(C)=O>[NH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH:9]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21081084HCID 21081084, compound

Product 1

HCID 21081086HCID 21081086, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Melting point 91-94° C. 13 g of 3-[4-(acetylamino-methyl)-cyclohexyl]-propionic acid are added to 200 ml of semi-concentrated aqueous hydrochloric acid and the resulting solution is refluxed overnight. The mixture is combined with acetone, recrystallised and the precipitate is separated off. When the mother liquor is concentrated step by step further fractions of the crystallin product are isolated. The fractions are combined, recrystallised with isopropanol and then dried.

Workup

  1. temperaturethe resulting solution is refluxed overnight
  2. customrecrystallised
  3. customthe precipitate is separated off
  4. concentrationWhen the mother liquor is concentrated step by step further fractions of the crystallin product
  5. customare isolated
  6. customrecrystallised with isopropanol
  7. customdried

Sources & evidence

ORD record
ord-dcbea7b0f43a41f294a6524ebae7fb82
Source dataset
uspto-grants-2010_05
Patent number
US07709480B2

Reaction notes

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