HCID 68448107, compound → HCID 86623073, compound

HRID 2233187Notes

Reaction equation

HRID 2233187 reaction equation
[OH:1][CH2:2][C:3]1[N:19]=[CH:18][C:6]2[O:7][CH2:8][CH2:9][N:10]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C:5]=2[CH:4]=1>ClCCl.[O-2].[Mn+4].[O-2]>[CH:2]([C:3]1[N:19]=[CH:18][C:6]2[O:7][CH2:8][CH2:9][N:10]([C:11]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:12])[C:5]=2[CH:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 68448107HCID 68448107, compound

Product 1

HCID 86623073HCID 86623073, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 1,1-dimethylethyl 7-(hydroxymethyl)-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate (0.78 g, 2.9 mmol) in dichloromethane (100 ml) was treated with manganese(IV) oxide (2.02 g, 23.3 mmol) and stirred overnight. Filtration and evaporation afforded a white solid (0.62 g, 81%).

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-81f98bd569134c77ae1bf8a85f7b5306
Source dataset
uspto-grants-2010_05
Patent number
US07709483B2

Reaction notes

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