HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2233273Generated: October 26, 2026
6-Heptynoic acid → 7-(4,5-Diphenylpyrimidin-2-yl)-6-heptynoic Acid
https://huagongshe.com/reaction/2233273
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 6-Heptynoic acid | HCID 4377950 | — |
| Reactant | 2-Chloro-4,5-diphenylpyrimidine | HCID 12674276 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 7-(4,5-Diphenylpyrimidin-2-yl)-6-heptynoic Acid | HCID 17757369 | 3.4% |
Reaction Steps
88 mg (0.7 mmol) of 6-heptynoic acid, 6 mg (0.07 eq.) of copper(I) iodide and 14 mg (0.04 eq.) of bis(triphenylphosphine)palladium(II) chloride were added to a solution of 114 mg (0.5 mmol) of 2-chloro-4,5-diphenylpyrimidine in 5 ml of triethylamine, and the mixture was stirred at 50° C. for 1 hour. The residue after evaporation was purified by preparative HPLC (method A). 6 mg (3%) of the desired product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709490B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-9650b360b9f14ad5afe6d2401338778e |
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| Source note | uspto-grants-2010_05 |
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