反应详情

温度

50 °C

25.0 g 1-Methyl-cyclohexanecarboxylic acid amide was suspended in 40 ml ethanol and warmed to 50° C. At this temperature 29.0 ml Ethyl 2-chloroacetoacetate were added and the reaction mixture heated under reflux overnight. The cooled reaction mixture was evaporated under reduced pressure and the resulting residue was purified by chromatography with the eluent petroleum ether:ethyl acetate=4:1 to obtain 21.0 g 4-Methyl-2-(1-methyl-cyclohexyl)-oxazole-5-carboxylic acid ethyl ester as an oil which solidifies upon standing.

1. temperaturethe reaction mixture heated
2. temperatureunder reflux overnight
3. customThe cooled reaction mixture
4. customwas evaporated under reduced pressure
5. customthe resulting residue was purified by chromatography with the eluent petroleum ether