Aniline → 4-Carbamoyl-1-phenyl-pyridinium hydrochloride

HRID 2233284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2233284
[ClH:1].[C:2]([C:5]1[CH:10]=[CH:9][N+:8]([C:11]2[CH:16]=[CH:15][C:14]([N+]([O-])=O)=[CH:13][C:12]=2[N+]([O-])=O)=[CH:7][CH:6]=1)(=[O:4])[NH2:3].NC1C=CC=CC=1>CO>[ClH:1].[C:2]([C:5]1[CH:6]=[CH:7][N+:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:9][CH:10]=1)(=[O:4])[NH2:3]

Komponenten

4

Edukt 2

HCID 6115AnilineHCID 867611004-Carbamoyl-1-(2,4-dinitrophenyl)-pyridinium chloride

Produkt 1

HCID 686786254-Carbamoyl-1-phenyl-pyridinium hydrochlorideAusbeute 125,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 30.0 g 4-Carbamoyl-1-(2,4-dinitro-phenyl)-pyridinium hydrochloride and 22.4 g aniline in 600 ml methanol was stirred at room temperature for four days. The suspension was warmed to 55° C. and stirred at this temperature for one hour. The resulting solution was cooled and the solvent removed in vacuo. The resulting residue was suspended in 300 ml propan-2-one and stirred at room temperature. The insoluble residue was filtered and dried in vacuo to obtain 27.3 g 4-Carbamoyl-1-phenyl-pyridinium hydrochloride.

Aufarbeitung

  1. temperatureThe suspension was warmed to 55° C.
  2. stirringstirred at this temperature for one hour
  3. temperatureThe resulting solution was cooled
  4. customthe solvent removed in vacuo
  5. stirringstirred at room temperature
  6. filtrationThe insoluble residue was filtered
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f2cbee37e2b34269b6837f013106c0b8
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709481B2

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