HCID 59295378, compound → HCID 59295412, compound

HRID 2233292Notes

Reaction equation

HRID 2233292 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:9][C:8]([C:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]=2)=[N:7][C:6]=1[CH2:16][O:17][CH3:18])=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([C:5]1[O:9][C:8]([CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]2)=[N:7][C:6]=1[CH2:16][O:17][CH3:18])=[O:4]

Participants

4

Reactant 1

HCID 59295378HCID 59295378, compound

Product 1

HCID 59295412HCID 59295412, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5.30 g 2-Cyclohex-1-enyl-4-methoxymethyl-oxazole-5-carboxylic acid methyl ester were dissolved in 40 ml methanol. 500 mg palladium on charcoal (10%) were added and the reaction mixture was stirred under an atmosphere of hydrogen overnight. The catalyst was filtered off through a pad of celite, the filtrate was evaporated in vacuo to obtain 4.70 g 2-Cyclohexyl-4-methoxymethyl-oxazole-5-carboxylic acid methyl ester as an oil.

Workup

  1. filtrationThe catalyst was filtered off through a pad of celite
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-44f9874247104dd3938c755b4a13274e
Source dataset
uspto-grants-2010_05
Patent number
US07709481B2

Reaction notes

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