HCID 59295396, compound → HCID 59295435, compound

HRID 2233294Notes

Reaction equation

HRID 2233294 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:10][C:9]([C:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]=2)=[N:8][C:7]=1[CH2:17][N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)=[O:5])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[O:10][C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:8][C:7]=1[CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 59295396HCID 59295396, compound

Product 1

HCID 59295435HCID 59295435, compoundYield 97.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

580 mg 2-Cyclohex-1-enyl-4-morpholin-4-ylmethyl-oxazole-5-carboxylic acid ethyl ester were dissolved in 15 ml methanol. 50 mg palladium on charcoal (10%) were added and the reaction mixture was stirred under an atmosphere of hydrogen for one hour. The catalyst was filtered off through a pad of celite, the filtrate was evaporated in vacuo to obtain 570 mg 2-Cyclohexyl-4-morpholin-4-ylmethyl-oxazole-5-carboxylic acid ethyl ester as an oil.

Workup

  1. filtrationThe catalyst was filtered off through a pad of celite
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-0175df0891b743339109ba8937a36c74
Source dataset
uspto-grants-2010_05
Patent number
US07709481B2

Reaction notes

Loading…